群馬大学大学院病態腫瘍薬理学・がん治療臨床開発学

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業績

2015

Iwakawa R, Kohno T, Totoki Y, Shibata T, Tsuchihara K, Mimaki S, Tsuta K, Narita Y, Nishikawa R, Noguchi M, Harris C, Robles A, Yamaguchi R, Imoto S, Miyano S, Totsuka H, Yoshida T, Yokota J. Expression and Clinical Significance of Genes Frequently Mutated in Small Cell Lung Cancers Defined by Whole Exome/RNA Sequencing. Carcinogenesis. 2015 Apr.
 
Tsuboi M, Yamane A, Horiguchi J, Yokobori T, Kawabata-Iwakawa R, Yoshiyama S, Rokudai S, Odawara H, Tokiniwa H, Oyama T, Takeyoshi I, Nishiyama M. APOBEC3B high expression status is associated with aggressive phenotype in Japanese breast cancers. Breast Cancer. 2015, s12282-015-0641-8.
 
Altan B, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Kogure N, Kimura A, Hara K, Bai T, Bao P, Suzuki M, Ogata K, Asao T, Nishiyama M, Oyama T, Kuwano H. Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients. Gastric Cancer. 2015 Oct.
 
Yokobori T, Bao P, Fukuchi M, Altan B, Ozawa D, Rokudai S, Bai T, Kumakura Y, Honjo H, Hara K, Sakai M, Sohda M, Miyazaki T, Ide M, Nishiyama M, Oyama T, Kuwano H. Nuclear PROX1 is Associated with Hypoxia-Inducible Factor 1α Expression and Cancer Progression in Esophageal Squamous Cell Carcinoma. Ann Surg Oncol. 2015 Aug.
 
Putra AC, Eguchi H, Lee KL, Yamane Y, Gustine E, Isobe T, Nishiyama M, Hiyama K, Poellinger L, Tanimoto K. The A Allele at rs13419896 of EPAS1 Is Associated with Enhanced Expression and Poor Prognosis for Non-Small Cell Lung Cancer. PLos One. 2015, 10(8).
 
Nishiyama M. [The Potential Role of an Academic Society for Oncology Specialists to Promote Cancer Education in Schools] Gan To Kagaku Ryoho. 2015 Aug;42(8):916-9. Japanese.
 
Takahashi H, Sakakura K, Kawabata R, Rokudai S, Toyoda M, Nishiyama M, Chikamatsu K. Immunosuppressive activity of cancer-associated fibroblasts in head and neck squamous cell carcinoma. Cancer Immunol lmmunother. 2015 Jul
 
Azuma Y, Yokobori T, Mogi A, Altan B, Yajima T, Kosaka T, Onozato R, Yamaki E, Nishiyama M, Asao T, Kuwano H. SIRT6 expression is associated with poor prognosis and chemosensitivity in patients with non-small cell lung cancer. Journal of Surgical Oncology. 2015 Jul, 10.1002.
 
Nikkuni O, Kaira K, Toyoda M, Shino M., Sakakura K, Takahashi K, Tominaga H, Oriuchi N, Suzuki M, Iijima M, Asao T, Nishiyama M, Nagamori S, Kanai Y, Oyama T, Chikamatsu K. Expression of Amino Acid Transporters(LAT1 and ASCT2) in Patients with Stage Ⅲ/Ⅳ Laryngeal Squamous Cell Carcinoma. Pattrology&Oncology Research. 2015 Jul, DOI:10.1007/s 12253-015-9954-3.
 
Yatabe T, Taniguchi Y, Nishiyama M, Inoue K, Ikezoe T, Fujimoto S, Terada Y, Yokoyama M. Lactic acidosis and asymptomatic hypoglycaemia due to plasmablastic lymphoma. Anaesth Intensive Care. 2015 May;43(3):416-7.

 

2014

Furuhata T, Hirata K, Wakao F, Okita K, Imamura M, Maehara Y, Nishiyama M: Questionnaire survey for the development and publication of cancer clinical practice guidelines in Japan. Int J Clin Oncol, 19(5):771-8, 2014.

 

Umemura S, Mimaki S, Makinoshima H, Tada S, Ishii G, Ohmatsu H, Niho S, Yoh K, Matsumoto S, Takahashi A, Morise M, Nakamura Y, Ochiai A, Nagai K, Iwakawa R, Kohno T, Yokota J, Ohe Y, Esumi H, Tsuchihara K, Goto K.: Therapeutic Priority of the PI3K/AKT/mTOR Pathway in Small Cell Lung Cancers as Revealed by a Comprehensive Genomic Analysis. J Thorac Oncol, 9(9):1324-31, 2014.

 

Uekita T, Fujii S, Miyazawa Y, Iwakawa R, Narisawa-Saito M, Nakashima K, Tsuta K, Tsuda H, Kiyono T, Yokota J, Sakai R.: Oncogenic Ras/ERK Signaling Activates CDCP1 to Promote Tumor Invasion and Metastasis. Mol Cancer Res, 12(10):1449-59, 2014.

 

Otsubo C, Otomo R, Miyazaki M, Mastushima-Hibiya Y, Kohno T, Iwakawa R, Takeshita F, Okayama H, Ichikawa H, Saya H, Kiyono T, Ochiya T, Tashiro F, Nakagama H, Yokota J, Enari M.: TSPAN2 Is Involved in Cell Invasion and Motility during Lung Cancer Progression.

Cell Rep, 7(2):527-38, 2014.

 

Ragin C, Obikoya-Malomo M, Kim S, Chen Z, Flores-Obando R, Gibbs D, Koriyama C, Aguayo F, Koshiol J, Caporaso NE, Carpagnano GE, Ciotti M, Dosaka-Akita H, Fukayama M, Goto A, Spandidos DA, Gorgoulis V, Heideman DA, van Boerdonk RA, Hiroshima K, Iwakawa R, Kastrinakis NG, Kinoshita I, Akiba S, Landi MT, Liu HE, Wang JL, Mehra R, Khuri FR, Lim WT, Owonikoko TK, Ramalingam S, Sarchianaki E, Syrjanen K, Tsao MS, Sykes J, Hee SW, Yokota J, Zaravinos A, Taioli E.: HPV-Associated Lung Cancers: an International Pooled Analysis. Carcinogenesis, 35(6):1267-75, 2014.

 

Romero OA, Torres-Diz M, Pros E, Savola S, Gomez A, Moran S, Saez C, Iwakawa R, Villanueva A, Montuenga LM, Kohno T, Yokota J, Sanchez-Cespedes M.: MAX inactivation in small-cell lung cancer disrupts the MYC-SWI/SNF programs and is synthetic lethal with BRG1.

Cancer Discov, 4(3):292-303, 2014.

 

Yoshiyama, S., Chen, Z., Okagaki, T., Kohama, K., Kawaharada, R., Izumi, T., Ohshima, N., Nagai, T., and Nakamura, A.: Nicotine exposure alters human vascular smooth muscle cell phenotype from a contractile to a synthetic type. Atherosclerosis, 237: 464-70, 2014.

 

Nishiyama M. Surviving Cancer in Asia. Jpn J Clin Oncol, 2014

 

2013

Suzuki T., Wada S., Eguchi H., Adachi J., Mishima K., Matsutani M., Nishikawa R., Nishiyama M. Cadherin13 overexpression as an important factor related to the absence of tumor fluorescence in 5-aminolevulinic acid-guided resection of glioma. J. Neurosurg, 119(5):1331-9, 2013.11.

 

Nasu-Kawaharada R. 1, Nakamura A. 2, Kakarla S.K. 3, Blough E.R. 3, Kohama K. 2, Kohama T. A maternal diet rich in fish-oil may improve cardiac Akt-related signaling in the offspring of diabetic mother rats. Nutrition, 29(4):688-692, 2013.

 

Kouzine F.*, Wojtowicz D.*, Yamane A.*, Resch W., Kieffer-Kwon KR., Bandle R., Nelson S., Przytycka T., Levens D., Casellas R. Global regulation of promoter melting in naive lymphocytes. Cell, 2013 *equally contributed.

 

Di Virgilio M.*, Callen E.*, Yamane A.*, Zhang W.*, Jankovic M., Gitlin AD., Feldhahn N., Resch W., Oliveira TY., Chait BT., Nussenzweig A., Casellas R., Robbiani DF., Nussenzweig MC. Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching.  Science. 339 (6120):711-5, 2013 *equally contributed

 

Rokudai, S., Laptenko,O., Arnal,SM., Taya,Y., Kitabayashi,I. and Prives, C. MOZ increases p53 acetylation and premature senescence through its complex formation with PML. Proc Natl Acad Sci USA. 110(10):3895-3900, 2013. 

 

2012

Kawamura K., Takakura K., Mori D., Ikeda K., Nakamura A., Suzuki T. Tunicate cytostatic factor TC14-3 induces a polycomb group gene and histone modification through Ca2+ binding and protein dimerization. BMC Cell Biol 13: 1-13, 2012.

 

Zhang Y., Kawamichi H., Tanaka H., Yoshiyama S., Kohama K., Nakamura A. Calcium-dependent regulation of the motor activity of recombinant full-length Physarum myosin. J Biochem 152:185-190. 2012.

 

Nalabotu Siva K., Takatsuki H., Kolli M., Frost L., Crowder B., Yoshiyama S., Gadde Murali K., Kakarla Sunil K., Kohama K., Kumar A., Blough Eric R. Control of Myosin Motor Activity by the Reversible Alteration of Protein Structure for Application in a Bionanodevice. Adv Sci Lett 16(1): 213-221, 2012.

 

Sano H., Wada S., Eguchi H., Osaki A., Saeki T., Nishiyama M.  Quantitative prediction of tumor response to neoadjuvant chemotherapy in breast cancer: novel marker genes and prediction model using the expression levels.  Breast Cancer 19(1):37-45, 2012.

 

Nie Z., Hu G., Wei G., Cui K., Yamane A., Resch W., Wang R., Green D.R., Tessarollo L., Casellas R., Zhao K., Levens D.  c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells.  Cell 151(1):68-79, 2012.

 

Hakim O.*, Resch W.*, Yamane A.*, Klein I., Kieffer-Kwon K.R., Jankovic M., Oliveira T., Bothmer A., Voss T.C., Ansarah-Sobrinho C., Mathe E., Liang G., Cobell J., Nakahashi H., Robbiani D.F., Nussenzweig A., Hager G.L., Nussenzweig M.C., Casellas R.  DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes.  Nature 484(7392):69-74, 2012. *equally contributed

 

Kovalchuk A.L., Ansarah-Sobrinho C., Hakim O., Resch W., Tolarova H., Dubois W., Yamane A., Takizawa M., Klein I., Hager G.L., Morse H.C. 3rd, Potter M., Nussenzweig M.C., Casellas R.  Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation. Proc Natl Acad Sci USA. 109(27):10972-7, 2012.

 

2011

Yoshiyama S., Horinouchi T., Miwa S., Wang H.H., Kohama K., Nakamura A. Effect of Cigarette Smoke Components on Vascular Smooth Muscle Cell Migration Toward Platelet-Derived Growth Factor BB.  J Pharmacol Sci 115(4): 532-535, 2011.

 

Thatcher S.E., Fultz M.E., Tanaka H., Hagiwara H., Zhang H.L., Zhang Y., Hayakawa K., Yoshiyama S., Nakamura A., Wang H.H., Katayama T., Watanabe M., Lin Y., Wright G.L., Kohama K.  Myosin light chain kinase/actin interaction in phorbol dibutyrate-stimulated smooth muscle cells.  J Pharmacol Sci 116: 116-127, 2011.

 

Yamane A.*, Resch W.*, Kuo N., Kuchen S., Li Z., Sun H.W., Robbiani D.F., McBride K., Nussenzweig M.C., Casellas R. Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol 12(1):62-69, 2011.

 

2010

Zang Y., Nakamura A., Kawamich, H., Yoshiyama S., Katayama K., Kohama K. Calcium regulation of the ATPase activity of Physarum and scallop myosins using hybrid smooth muscle myosin: The role of the essential light chain. FEBS Lett 584: 3486-3491, 2010.

 

Katayama T., Watanabe M., Tanaka H., Hino, M., Miyakawa, T., Ohki, T., Ye, L.H., Xie, C., Yoshiyama, S., Nakamura, A., Ishikawa, R., Tanokura, M., Oiwa, K., Kohama, K. Stimulatory effects of arachidonic acid on myosin ATPase activity and contraction of smooth muscle via myosin motor domain. Am J Physiol Heart Circ Physiol 298: H505-H514, 2010.

 

Watanabe M., Yumoto M., Tanaka H., Wang H.H., Katayama T., Yoshiyama S., Black J., Thatcher S.E., Kohama K. Blebbistatin, a myosin II inhibitor, suppresses contraction and disrupts contractile filaments organization of skinned taenia cecum from guinea pig.  Am J Physiol Cell Physiol 298(5): C1118-1126, 2010.

 

Yoshiyama S., Ishigami M., Nakamura A., Kohama K. Calcium wave for cytoplasmic streaming of Physarum polycephalum. Cell Biol Int 34: 35-40, 2010

 

2009

Nishiyama M., Eguchi H.  Pharmacokinetics and pharmacogenomics in gastric cancer chemotherapy.  Adv Drug Deliv Rev 61(5): 402-407, 2009.

 

Fumoto S., Tanimoto K., Hiyama E., Noguchi T., Nishiyama M., Hiyama K.  EMP3 as a candidate tumor suppressor gene for solid tumors.  Expert Opin Ther Targets 13(7):811-822, 2009.

 

Higashi-Fujime S., Nakamura A.  Cell and molecular biology of the fastest myosins. Int Rev Cell Mol Biol. 276: 301-347, 2009.

 

Xie C., Zhang Y., Wang H. H., Matsumoto A., Nakamura A., Ishikawa R., Yoshiyama S., Hayakawa K., Kohama.K., Gao Y.  Calcium regulation of non-kinase activities of recombinant myosin light-chain kinase and its mutants.  IUBMB Life 61: 1092-1098, 2009.

 

Wang H. H., Nakamura A., Matsumoto A., Yoshiyama S., Qin X., Ye L.-H., Xie. C., Zhang Y., Ga, Y., Ishikawa R., Kohama K.  Nonkinase activity of MLCK in elongated filopodia formation and chemotaxis of vascular smooth muscle cells toward sphingosylphosphorylcholine.  Am J Physiol Heart Circ Physiol 296: H1683-1693, 2009.

 

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